Our Research Interest

Our Research Interest

I am a developmental neurobiologist and psychiatrist who has been NIH-funded since 1998. The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain in relation to neuropsychiatric disease. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human embryonic stem cells in cell culture and transplantation experiments to study the development of the cerebral cortex. We are particularly focused on the fate determination of key subclasses of cortical inhibitory interneurons.

Some current major projects in the lab include

  1. Acceleration of the maturation for human stem cell derived neurons by reversible activation of mTOR signaling
  2. Use of stem cell derived inhibitory interneurons transplants to correct circuit pathology and abnormal social behaviors in a mouse model of Dravet's syndrome autism
  3. Mitochondrial deficits in iPS derived neurons from patients with schizophrenia and the 22q11 deletion syndrome

I am also committed to the training and career development of undergraduates, graduate students, postdoctoral fellows and research technicians in our group.

Dr. Anderson

Dr. Anderson

Stewart Anderson MD., Professor of Psychiatry, at the University of Pennsylvania’s Perelman School of Medicine. Dr. Anderson also serves at Director of Research for the Department of Child and Adolescent Psychiatry and Behavioral Services of the Children’s Hospital of Philadelphia (CHOP), and as the Associate Director of the Lifespan Brain Institute, a CHOP-Penn collaboration dedicated to identifying the neuropathological antecedents of neuropsychiatric disease. He is a member of the Scientific Council for the Brain and Behavior Research Foundation (formerly NARSAD), and is a standing member on the Neural Cell Fate study section at the National Institutes of Health.

Dr. Anderson’s interest in the interface between basic science and clinical research extends to undergraduate training at Amherst College, where he majored in Neuroscience and in Psychology. His medical training at the University of Connecticut include two research fellowships at the National Institute of Mental Health, and his residency in Psychiatry at the University of Pittsburgh included studies with Dr. David Lewis on development of the cerebral cortex and schizophrenia. Dr. Anderson then trained in developmental neurogenetics with Dr. John Rubenstein at UCSF, before starting his own laboratory at the Weill Cornell Medical College, where he also worked with patients with treatment-resistant forms of schizophrenia

Dr. Anderson moved to UPenn and CHOP in 2012. The main focus of his laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. Using mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human embryonic stem cells in cell culture and transplantation experiments, they study the development of the cerebral cortex. They are particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia. New directions in the Anderson lab include the study of mitochondria in interneuron migration, maturation, and function. In addition, they are generating mouse and human stem cell-derived interneurons for use in cell-based therapies for seizures, psychotic disorders, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease.